Background
Breast cancer is a heterogeneous disease such that they may have different prognoses and respond to therapy differently despite similarities in histological types, grade and stage. Based on the presence or absence of expression of the estrogen receptor (ER), breast cancer is divided in two groups: ER+ and ER-. Genetic expression profile has identified two subtypes of the ER+ tumors: luminal A and luminal B. ER- tumors also include two subtypes, the HER2+ and the basal type. These subtypes differ in their biology and both demonstrate short disease-free periods after treatment and poorer outcome. In Morocco, it’s the first cancer in women and is currently a major public health problem. The molecular classification in breast carcinomas is now based upon gene expression analysis using DNA microarrays and allows to identify at least five groups: luminal A, luminal B, HER2-overexpressing, basal-like and normal breast-like [1–3]. However, large-scale subtyping using gene expression profiling from formalin-fixed, paraffin-embedded samples is not currently feasible and remains very expensive. Therefore, immunohistochemical markers have been used as surrogates tools for DNA microarray in subtyping breast cancer [4,5]. Several studies used routinely panels of immunohistochemical markers to classify breast cancers into subtypes similar to those previously defined using gene expression analyses [6]. The recent study was realized by Prat et al. [4]. They defined several immunohistochemical subtypes: (luminal A, Luminal B, HER2- enriched, basal-like) and a normal breast-like group that show significant differences in incidence, survival and response to therapy. Luminal A (ER positive (ER+) and/or PR positive (PR+), Her2 negative (Her2-)) with ki67<14%, luminal B (ER + and/or PR+ with ki67>14%, Her2 positive or negative (Her2+/-), Her2+/ER − subtype (Her2+, ER−, PR−) and basal-like (ER−, PR−, Her2−, Cytokeratin 5/6 positive (CK5/6+) and/or Her1+ (EGFR)). Tumors which were negative at immunohistochemical staining for all markers (ER, PR, Her2, Her1, and CK5/6) were considered unclassified subtype [4]. According to this classification, we performed immunohistochemical staining for ER, PR, Her2, Her1, CK8/18, basal CK5/6 and KI67 in paraffin sections from blocks of breast cancer. The aim of the present study was to estimate the prevalence of breast cancer subtypes in patients of the north east region of Morocco, and to correlate between clinical and pathological characteristics
| Référence | 2800 |
| Année | 2013 |
| Type | Article |
| Lien document | |
| Lien externe | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538531/ |
| Disciplines associées | Gynécologie Obstétrique 1, Oncologie Médicale |
| Auteur | El fatemi H |
| Auteurs associés | Chahbouni S, Jayi S, Moumna K, Melhouf MA, Abdelaziz Bannani, Mesbahi O, Amarti A |
| Discipline | Laboratoire |
| Revue | Diagn Pathol |
| Référence Revue | 0,409722222 |
