|Auteur||Gloria henewaa G|
Pharmacogenetics is the study of genetic differences in metabolic pathways that influence an individual’s response to drug. Genetic factors account for 15-30% of the variability in drug response, however for some drugs this could be the major determinant in drug response. Pharmacogenetics aims to identify genetic sources of variability in response to drugs by studying genetic variations affecting drug metabolizing enzymes, transportersand drug targets thus causing inter-individual variability in drug levels (pharmacokinetics), drug response (pharmacodynamics) and side effects. The objectives of our work are: to report the Experience of the Hassan II University Hospital, Fes; to evaluate the challenges of this field in Morocco and propose some recommendations. We report a study of the Medical Genetics Department of the Hassan II University Hospital, Fes aimed at studying the most common mutant alleles of the Thiopurine Methyl Transferase (TPMT) gene ; TPMT*2; TPMT*3A ,TPMT*3C in 103 Moroccan patients. The results showed no mutant alleles among the 206 alleles tested, thereby explaining why Moroccans show little or no toxicity to thiopurine drugs. We also report the different therapeutic choices in colorectal cancer and how the genetic polymorphisms coding for the metabolizing enzymes affect the response to these drugs. It is important to develop this field in Morocco, by developing the concept of personalized medicine where treatment is tailored to suit the genetic make-up of each individual with the aim of improving treatment efficacy while reducing toxicity.