Epigenetics could explain some Moroccan population colorectal cancers peculiarities: microsatellite instability pathway exploration

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Disciplines associéesGastroentérologie, Chirurgie viscérale A, Chirurgie viscérale B, Oncologie Médicale, Epidémiologie
AuteurSekal M
Auteurs associésAmeurtesse H, Chbani L, Ouldim K, Bennis S, El abkari M, Boulouz A, Benajah d A, Benjelloun B, Ousadden A, Ait taleb K, Ait laalim S, Mazaz K, Arifi S, Mellas N, El rhazi K, Harmouch T, Ibrahimi SA, Amarti riffi A
RevueDiagnostic Pathology
Référence Revue0,470138889

younger population in Morocco compared to what found in developed countries. The purpose of this study is to confirm these CRC peculiarities in Morocco and try to explain them by exploring the microsatellite instability molecular pathway.

This is a prospective observational study conducted since January 2010, including 385 patients admitted in Hassan II University Hospital of Fez. We collected clinical, radiological and pathological data. We investigated the expression of mismatch repair (MMR) proteins in 214 patients and BRAF gene mutations in 159 patients.

Mean age was 55.08 +/- 15.16 years. 36.5% of patients were less than 50 years old and 49.3% of tumors were localized in the rectum. Loss of MMR protein expression was observed in 11.2% of cases. It was independently associated with individual or family history of cancer belonging to Hereditary Non-Polyposis Colorectal Cancer (HNPCC) spectrum (p = 0.01) and proximal localization (p = 0.02). No BRAF mutation was detected in all cases.

These results confirm the high occurrence of CRCs to young patients and the high frequency of rectal localizations in Moroccan population. They mostly show an absence of BRAF mutation, supposing a rarity of MLH1 promoter hypermethylation pathway, which may even partially explain the CRC peculiarities in our context