Systemic lupus erythematosus (SLE) and small-sized vessel vasculitis are usually two distinguishable
autoimmune diseases. We report a case of novo SLE associated with cytoplasmatic antineutrophil
cytoplasmatic antibodies (c-ANCA). A 34-year old woman was admitted to our hospital for purpura, weight
loss, inflammatory polyarthralgia and nasal stuffiness with advanced renal failure. The investigations have
revealed positive immunological test (ANN, anti-DNA and c-ANCA). Renal biopsy showed a diffuse
proliferative lupus nephritis (class IV-G (A)) with necrotizing crescentic glomerulonephritis. We have
retained the diagnosis of SLE associated to c-ANCA. She has received corticosteroids and
cyclophosphamide. The evolution was marked by the occurrence of alveolar hemorrhage that caused her
death