Syndrome malin des neuroleptiques (A propos de 14 cas)

Neuroleptic malignant syndrome is potentially deadly but a rare condition occurs when taking neuroleptics. It is characterized by hyperthermia, severe extrapyramidal disorders and neuro-vegetative disturbances. We have studied retrospectively files of 14 patients hospitalized for NMS In the psychiatric department of Hassan II University Hospital of Fes in the last six years, in order to search for the causes its occurrence and planning its development. 86% of our patients are male, and the average age is 29. This disease usually affects young males but the risk of its development is increasing with certain factors. According to our results, it seems that high potency neuroleptics (73%), particularly haloperidol and parenteral administration (57%) appear to be strongly associated with NMS especially in agitated patients having a psychotic disorder (78%) or if antipsychotic treatment is newly introduced (64%). Combining several drugs is very common in our results, 50% with other antipsychotics, 81% with benzodiazepines. Physical impacts associated are somehow less frequent (42%) but also seem to have a role in the occurrence known NMS. Mortality rate was 7% (only 1 patient). These data are consistent with the majority of international works. Our results emphasize the necessity for rational use of antipsychotics among people at risk, the importance of early diagnosis and immediate treatment in order to have a positive development.

Référence1381
Année2014
TypeThèse
Lien document
AuteurZahfir I
DisciplinePsychiatrie
EncadrantRammouz I