Introduction: the aim of this work is to study predictors of sustained virological response after antiviral treatment for chronic hepatitis C “in real life”.
Methods:This is a retrospective study of cases of chronic hepatitis C treated in our department. All clinical, laboratory and histology data were collected and analyzed from the files and registry of patients treated and followed for chronic viral hepatitis C infection.
Results:234 patients with chronic hepatitis C virus were seen in our department, and 101 were treated. Eighty-eight patients completed their treatment and their follow-up 6 month after the end of treatment, their average age was 57,3 years [17-77], with female predominance (sex ratio 0.9), genotype 1: 53 % (47/88), genotype 2: 42% (37/88). Eight percent of patients (7 / 88) were cirrhotic. The viral load at the end of treatment was negative in 72.7% (64/88) of patients for all genotypes. The sustained viral response was 47.7% of patients for all genotypes. (34% (16/47) for genotype 1 and 62% (23/37) for genotype 2). In univariate analysis predictors factors of SVR was genotype 2 and pegylated combination therapy but they are not independent factors of SVR in multivariate analysis.
Conclusion: The average age of patients was 57.3 years, fibrosis was severe in 27% of cases. There was a predominance of genotype 1 (53%) and genotype 2 (42%). The SVR was 47.7%. In univariate analysis predictors factors of SVR were genotype 2 and pegylated combination therapy but they were not independent factors of SVR in multivariate analysis.