Squamous cellcarcinomaarisingfromperinealfistulainpatientswithCrohn’sdisease(CD)isa
rare entity,withfewreportedcasesintheliteraturemakingitsclinicalcharacterization
troublesome. Theoutcomeispoorfollowingoperativetreatmentasthemalignancyofchronic
perineal fistulainCrohn’sdiseaseisusuallyoverlookedandtardilydiagnosed.Wepresenta
unique caseofa47-year-oldmanwitha20-yearhistoryofchronicperinealfistulathatwas
diagnosed withextensiveperinealsquamouscellcarcinomaextendingdowntotherightthigh.
Computer tomographyshowedlocallyadvanceddiseasewithinguinalandlungmetastasis.
Treatment wasconsistedofdivertingcolostomyandpalliativecare.Thepatientdied3months
later. Theclinicaldataandclinicopathologicalfeaturesofreportedcasesintheliteraturewere
reviewed