Introduction: Verrucous carcinoma of the external genitalia and perianal region is a rare variant of well-differentiated
squamous cell carcinoma. It has been reported to have limited metastatic potential.
Case presentation: We report the case of a 54 year-old Moroccan man who presented with locally advanced giant
condyloma acuminatum (Buschke–Löwenstein tumor) after prolonged intervals of neglect (approximately 10 years). The
disease covered his suprapubic, external genitalia and perianal region. It was locally aggressive with extensive tissue
destruction. After a biopsy of the lesion, the diagnosis of verrucous carcinoma was confirmed. He initially received
chemoradiotherapy, followed by extensive local excision, but he developed septic shock and died a few days later.
Conclusions: The purpose of this case report is to present a case of verrucous carcinoma arising in an extensive giant
condyloma acuminatum (Buschke–Löwenstein tumor) and discuss the literature on its diagnosis and management