Introduction: Chronic lead poisoning is a public health problem in developed countries but still underestimated in developing countries. In Morocco, in addition to the common causes of lead exposure, could be added specific causes such as the use of lead-based cookware, use of medicines and cosmetics containing lead including Kohl. It is in this context we propose to do a screening for a family who product Kohl in the old Medina of Fez for lead toxicity. Purpose o f th i s study : Make a lead poisoning screening for a family of artisanal manufacturers of Khol and evaluate the impregnation of lead in this family. Materials and Methods: This is a descriptive cross-sectional study spanning a period of 08 months in a family of 12 patients (07 children and 05 adults). At each of our patients, anamnestic information was collected and toxicological samples (blood lead levels) were performed. The clinical and biological disturbances associated were detected through clinical examination, blood and urine laboratory tests. Results: The study involved a family of 12 patients. The average age of our patients was 25.25 years with a female predominance of 66.66% and a sex ratio M / F 0.5. Note that 58.33% of our patients were children with an age between 3 and 13 years. The clinical examination was made by the general signs (3 people), intestinal symptoms (2 patients), neurological signs (4 patients), and non-specific signs (2 patients). The diagnosis was made by measurement of blood lead levels that were very high with an average of 425.94 µg/l. The prevalence of lead poisoning at screening was 91.66 %. The assumption was based on cessation of exposure, lifestyle changes and specific treatment for patients poisoned by specific chelator of lead. A follow up revealed a significant decrease in blood lead control with an average of 158.04 µg / l against 425.94 µg / l at screening. The prevalence of lead poisoning decreased from 91.66% at screening to 75% after cessation of exposure and chelation therapy. Conclusion: Artisanal manufacturers of Khol possess an increased risk for lead poisoning. Screening programs need to be implented in reason to educate Khol workers about preventives and correctives measures against lead poisoning