Systemic elastorrhexis is a multisystem genetic disorder characterised by dystrophic mineralization of soft connective tissues in a number of
organs, including the skin, the eyes and the arterial blood vessels. Although the eye and skin findings have for years attracted the attention of
ophthalmologists and dermatologists, the systemic nature of the disorder has not received sufficient attention among internists and many patients
with this disorder have undoubtedly been unrecognized. We reported a case of systemic elastorrhexis redressing the diagnosis of vascular
leucoencephalopathy of an unknown aetiology for many years. Key words: Systemic elastorrhexis, pseudoxanthoma elasticum, Gronblad-
Strandberg-Touraine