Sister Joseph nodule is a metastatic umbilical lesion secondary to a primary
malignancy of any viscera. The majority of cases originate from gastrointestinal
or ovarian cancer. It is an uncommon clinical sign, which reveals the poor
prognosis of these malignancies. Here, we present 3 such cases, with Sister Joseph
nodule metastasing from bilio-pancreatic tract. The clinicopathologic features
of all 3 patients are discussed, and the related literature is briefly reviewed